In Dushanbe, temperatures vary between a minimum -13°C (8°F) in December/January to a maximum 33°C (91°F) in July/August. Humidity is generally low. In the mountains, it can reach -45°C (-49°F) when the wind chill factor is taken into consideration, and rise to 20°C (68°F) in summer. In the Pamir Mountains, the climate is semi-arid to polar.

Warm clothing should be taken by anyone intending to visit the mountains. Those intending to visit the southwest in summer should bring light, loose clothing.